Basic Information
VIS ID
TVIS44009492
Fusion event
HTLV-1-ANKH integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
14861619/14861510 (Hg38)
End
14861619/14861510 (Hg38)
Orient
-
Location type
Intronic
Target gene
ANKH
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-92a-3p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-519c-3p ; hsa-mir-526b-3p ; hsa-mir-519b-3p ; hsa-mir-519d-3p ; hsa-mir-519a-3p ; hsa-mir-4325 ; hsa-mir-3924 ; hsa-mir-3668 ; hsa-mir-7852-3p ; hsa-mir-1264 ; hsa-mir-4796-3p ; hsa-mir-3609 ; hsa-mir-548ah-5p
Nearest miRNA
hsa-mir-10397/Upstream/35498; hsa-mir-103a-1/Downstream/1073672;
Nearest TSS
ENST00000502646/Upstream/73293; ENST00000607026/Downstream/8852;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/196404, chr5-CpG: 21/Downstream/9772
Upstream sequence
AATGTCCTAAGAAGCCTCAACCTCACTTTTGAAGCCATCTTTGAAACTCCCTATCTGAGGACTCTGCTCTGTTTTTGGATTTCTCCCCAGCCTGGAGCCA
Downstream sequence
GAGGTCCTCACTGGCATATTTCTGCCTGGGTGAGATAGCCTAGTGGGTGTGGTGTGTGGCAGTGCCTGTCACCTCCTCATGCTCCAGAGTACACAGCCAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate