Basic Information
VIS ID
TVIS44009506
Fusion event
HTLV-1-AP3B1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
77372982/78077158 (Hg38)
End
77372982/78077158 (Hg38)
Orient
+
Location type
Intronic
Target gene
AP3B1
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-9-5p ; hsa-mir-214-3p ; hsa-mir-421 ; hsa-mir-221-3p ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-1305 ; hsa-mir-6739-3p ; hsa-mir-375 ; hsa-mir-4677-5p ; hsa-mir-7156-5p ; hsa-mir-4273 ; hsa-mir-19b-2-5p ; hsa-mir-19b-1-5p ; hsa-mir-19a-5p ; hsa-mir-2052 ; hsa-mir-22-5p ; hsa-mir-2116-5p ; hsa-mir-4522 ; hsa-mir-627-3p ; hsa-mir-4431 ; hsa-mir-195-3p ; hsa-mir-16-2-3p ; hsa-mir-3664-5p
Nearest miRNA
hsa-mir-10397/Upstream/5198495; hsa-mir-103a-1/Downstream/4762997;
Nearest TSS
ENST00000502646/Upstream/33908; ENST00000510030/Downstream/36612;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/104195, chr5-CpG: 47/Downstream/217155
Upstream sequence
tggaggactgtgcctttaaccttgagtttggctacctCCAAGAGGCATACAACAACAAATTAGGCCTTTTTGTTTGTTTCATGGATTGTTCTTGAAATTC
Downstream sequence
CTTACTATTCCTCAGTGTACCACTTTTGCATTTTGAAATGATCACTTTTCTTAATGAGCCTTCCTGTACTGTCCAAAATTAAATTCCACTTAGGGTTTGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate