Basic Information
VIS ID
TVIS44009507
Fusion event
HTLV-1-ARSB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
78159297/78863474 (Hg38)
End
78159297/78863474 (Hg38)
Orient
+
Location type
Intronic
Target gene
ARSB
miRNAs that regulate target gene
hsa-mir-122-5p ; hsa-mir-941 ; hsa-mir-224-5p ; hsa-mir-6874-5p ; hsa-mir-7850-5p ; hsa-mir-505-5p ; hsa-mir-383-3p ; hsa-mir-320e ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-4684-5p ; hsa-mir-769-5p ; hsa-mir-4786-5p ; hsa-mir-3190-5p ; hsa-mir-454-5p ; hsa-mir-6849-3p ; hsa-mir-3675-3p ; hsa-mir-652-5p
Nearest miRNA
hsa-mir-10397/Upstream/5984811; hsa-mir-103a-1/Downstream/3976681;
Nearest TSS
ENST00000502646/Upstream/79980; ENST00000523472/Downstream/91900;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/214077, chr5-CpG: 116/Downstream/121020
Upstream sequence
agactggattaagaaaacatggcacatatacaccatggaatactgtacagccataaaaaaggacgagttcatgtcctttgtagggacatggatgaagctg
Downstream sequence
aaaaccatcactctgagcaaactatagcaaggacagaaaaccaaacactgcatgttctcactcataggtgggaattgaacaatgaggacacttggacacg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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