Basic Information
VIS ID
TVIS44009525
Fusion event
HTLV-1-NEDD9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p24.2
Reference genome
GRCh37/hg19
Start
11329327/11329094 (Hg38)
End
11329327/11329094 (Hg38)
Orient
-
Location type
Intronic
Target gene
NEDD9
miRNAs that regulate target gene
hsa-mir-18a-5p ; hsa-mir-145-5p ; hsa-mir-30c-5p ; hsa-mir-218-5p ; hsa-mir-6803-5p ; hsa-mir-6751-5p ; hsa-mir-642a-5p ; hsa-mir-4477a ; hsa-mir-5682 ; hsa-mir-7110-5p ; hsa-mir-6842-5p ; hsa-mir-6752-5p ; hsa-mir-6835-5p ; hsa-mir-5702 ; hsa-mir-520h ; hsa-mir-520g-3p ; hsa-mir-6871-3p ; hsa-mir-29c-3p ; hsa-mir-29b-3p ; hsa-mir-29a-3p ; hsa-mir-4506 ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-3912-3p
Nearest miRNA
hsa-mir-3691/Upstream/889300; hsa-mir-10398/Downstream/4812462;
Nearest TSS
ENST00000381078/Upstream/96412; ENST00000419796/Downstream/53178;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/234660, chr6-CpG: 182/Downstream/208210
Nearest cancer related gene
NEDD9(OG, No orient, 0)
Upstream sequence
TCTTCCCGTCTTTGGACTTGAGCCCCAGTGCCTGGCTGCAGAATTCCATGGTGAGGCACAAGCATGACATCATGTTCAGGAGGAATGCACAGCACATAAA
Downstream sequence
GTCTTGCCTGGGTCAGAGAGAAGTGCTAAGCCCTCAAGAGGGCCCTAAGACAAATGCACAAATATGGCCTAGCACATGTCAAACACCCGTGCAAGGGCAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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