Basic Information
VIS ID
TVIS44009532
Fusion event
HTLV-1-KHDRBS2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q11.1
Reference genome
GRCh37/hg19
Start
62956228/62246323 (Hg38)
End
62956228/62246323 (Hg38)
Orient
+
Location type
Intronic
Target gene
KHDRBS2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-148b-3p
Nearest miRNA
hsa-mir-10398/Upstream/4856111; hsa-mir-10524/Downstream/9130637;
Nearest TSS
ENST00000381078/Upstream/1523175; ENST00000370659/Downstream/39904;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/4284773, chr6-CpG: 45/Downstream/39627
Upstream sequence
TAGGATGTTCTTATCATAGTGAAGTATCTACAAAAGAGGATACAGGCAAGTTCTTTTTAAAGTAGTCAGCAAATTATATAGGCTAGCTGGACTTACATAA
Downstream sequence
TTTTGTATGTCACAAAACATATTTTCTCTGCCAACATATATCTGAGATACTCTATAAGAAAAACATTCACTTCTCCTTTCTTTTCTACTGCTAATAGTTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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