Basic Information
VIS ID
TVIS44009559
Fusion event
HTLV-1-CHCHD2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
56169657/56101964 (Hg38)
End
56169657/56101964 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA7A
Target gene
CHCHD2
miRNAs that regulate target gene
hsa-mir-320b ; hsa-mir-1229-3p ; hsa-mir-484 ; hsa-mir-221-3p ; hsa-mir-92a-3p ; hsa-mir-218-5p
Nearest miRNA
hsa-mir-1183/Upstream/11220164; hsa-mir-10399/Downstream/853821;
Nearest TSS
ENST00000635602/Upstream/8968; ENST00000566570/Downstream/4467;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/37431, chr7-CpG: 48/Downstream/4255
Upstream sequence
CAAACAGAAAAGATTAAGTTAGAAGAATGCTAGCTTCGTATACTCAATAAAACAGAAGCCTTCCAAATTATGAAAGCAGCGACAAAAGGCCAAGGCTATG
Downstream sequence
GGTTTTTTGTtttttgtttttttttgataaaaaatagagatgaggtcttgctatgttgcccaggctggtctcgaactcctggactcaagcaatcctccca
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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