Basic Information
VIS ID
TVIS44009568
Fusion event
HTLV-1-SLC26A5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
103036202/103395755 (Hg38)
End
103036202/103395755 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
SLC26A5
Nearest miRNA
hsa-mir-10525/Upstream/924224; hsa-mir-10399/Downstream/11257590;
Nearest TSS
ENST00000635602/Upstream/40899; ENST00000422488/Downstream/25767;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/50865, chr7-CpG: 28/Downstream/49508
Upstream sequence
gattacaggcacccgccaccatgcccggctaatttttgtatttttactagagatggggtttcaccatgtttgccaggctggtctggaactcctgaccttg
Downstream sequence
tgatccaccagcctcagcctcctaaagtgctgggattacaggagtctgccaccgtgcccggccAATAATATGTTTTAAAAATGTACAGTTAGATAATATA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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