VISDB - VIS Detail

Basic Information

VIS ID

TVIS44009575

Fusion event

HTLV-1-PPP2R2A integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr8

Cytoband

p21.2

Reference genome

GRCh37/hg19

Start

26160748/26303232 (Hg38)

End

26160748/26303232 (Hg38)

Orient

Location type

Intronic

Target gene

PPP2R2A

miRNAs that regulate target gene

hsa-mir-31-5p ; hsa-mir-222-3p ; hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-mir-30a-5p ; hsa-mir-26b-5p ; hsa-mir-92a-3p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-548t-5p ; hsa-mir-548az-5p ; hsa-mir-409-3p ; hsa-mir-551b-5p ; hsa-mir-605-3p ; hsa-mir-3910 ; hsa-mir-4796-3p ; hsa-let-7c-5p ; hsa-let-7d-5p ; hsa-let-7e-5p ; hsa-let-7f-5p ; hsa-mir-98-5p ; hsa-let-7g-5p ; hsa-let-7i-5p ; hsa-mir-4458 ; hsa-mir-4500 ; hsa-mir-218-5p ; hsa-mir-187-5p ; hsa-mir-154-5p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-3605-5p ; hsa-mir-3679-5p ; hsa-mir-1185-5p ; hsa-mir-4719 ; hsa-mir-4801 ; hsa-mir-4731-3p ; hsa-mir-101-3p ; hsa-mir-144-3p ; hsa-mir-3202 ; hsa-mir-4533 ; hsa-mir-556-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-1249-5p ; hsa-mir-1343-5p ; hsa-mir-143-3p ; hsa-mir-221-3p ; hsa-mir-3179 ; hsa-mir-363-5p ; hsa-mir-4274 ; hsa-mir-4459 ; hsa-mir-455-3p ; hsa-mir-4695-5p ; hsa-mir-4770 ; hsa-mir-5197-3p ; hsa-mir-548ao-3p ; hsa-mir-548v ; hsa-mir-555 ; hsa-mir-6081 ; hsa-mir-6088 ; hsa-mir-6515-5p ; hsa-mir-665 ; hsa-mir-6745 ; hsa-mir-6797-5p ; hsa-mir-6805-5p ; hsa-mir-6809-5p ; hsa-mir-6864-5p ; hsa-mir-6880-5p ; hsa-mir-7515 ; hsa-mir-766-5p ; hsa-mir-7847-3p ; hsa-mir-939-5p

Nearest miRNA

hsa-mir-124-1/Upstream/957758; hsa-mir-10400/Downstream/745621;

Nearest TSS

ENST00000518652/Upstream/4657; ENST00000640787/Downstream/35657;

Nearest CpG islands

None/Target, chr8-CpG: 109/Upstream/112651, chr8-CpG: 103/Downstream/79542

Upstream sequence

GTCTCCTCCCTCCCTGTTCTTTTAGATACCAAATTAGATCTGCCTTAAGCTCCTTCAGCTGGTGATCTTGGTGAAGGAAGAATACCTTCAGGACGTTAAA

Downstream sequence

GTATCTATTTTTAAACTTACCTCTCCCTTACAGAGATTAAATACCAGTAACATATTTGCCAGAATAAAATAATTTTTTACGGTTTTCCCCACAATGTCTG

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.