Basic Information
VIS ID
TVIS44009588
Fusion event
HTLV-1-NDUFAF6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
95996047/94983819 (Hg38)
End
95996047/94983819 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA8B
Target gene
NDUFAF6
miRNAs that regulate target gene
hsa-mir-3679-3p ; hsa-mir-6807-5p ; hsa-mir-6868-3p ; hsa-mir-6826-3p ; hsa-mir-2355-5p ; hsa-mir-1233-3p ; hsa-mir-1225-3p ; hsa-mir-3124-3p ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-129-2-3p ; hsa-mir-129-1-3p
Nearest miRNA
hsa-mir-12123/Upstream/1067700; hsa-mir-10400/Downstream/89092;
Nearest TSS
ENST00000518652/Upstream/2911; ENST00000522683/Downstream/41167;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/33675, chr8-CpG: 72/Downstream/40971
Nearby gene
TP53INP1(-34432) ;
Upstream sequence
ctaagatcatactatgagtggtagagccaggattcaaaccgaggtggtgtgcatccagagagtgtccagggtccacatcttaatcactCACCTGGTttcc
Downstream sequence
taaatgtgtctgtaccgaagagtcaccaaggggcacttattaaagtacagattccagggtctacctcagagatagcaaatcagggtctctaggggaggga
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate