Basic Information
VIS ID
TVIS44009590
Fusion event
HTLV-1-NUDCD1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q23.1
Reference genome
GRCh37/hg19
Start
110342172/109329943 (Hg38)
End
110342172/109329943 (Hg38)
Orient
-
Location type
Intronic
Target gene
NUDCD1
miRNAs that regulate target gene
hsa-mir-203a-3p ; hsa-mir-873-5p ; hsa-mir-205-3p ; hsa-mir-4538 ; hsa-mir-4453
Nearest miRNA
hsa-mir-12123/Upstream/4845478; hsa-mir-10400/Downstream/3313550;
Nearest TSS
ENST00000518652/Upstream/9; ENST00000522632/Downstream/4175;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/542330, chr8-CpG: 81/Downstream/3744
Upstream sequence
ATGGACATGGGACCCTTCAATACAAAATCAATAATCTTAGCAAAGAAAACATACTGGATGCTACGaagtatgataaagtctatgaagtactggttactat
Downstream sequence
ggcaacgcataatacagattctatagtgtagattctgactagtcaagaaaggaatccctgaggaagtaacatgtaagccaacatgaaagaatgaagtatg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate