Basic Information
VIS ID
TVIS44009605
Fusion event
HTLV-1-RUSC2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
35546801/35546804 (Hg38)
End
35546801/35546804 (Hg38)
Orient
+
Location type
Exonic
Target gene
RUSC2
miRNAs that regulate target gene
hsa-mir-324-5p ; hsa-mir-4762-3p ; hsa-mir-4674 ; hsa-mir-6749-3p ; hsa-mir-3192-3p ; hsa-mir-642a-5p ; hsa-mir-4437 ; hsa-mir-4268 ; hsa-mir-661 ; hsa-mir-3182 ; hsa-mir-378g ; hsa-mir-4502 ; hsa-mir-4469 ; hsa-mir-939-3p ; hsa-mir-877-3p ; hsa-mir-660-3p ; hsa-mir-5193 ; hsa-mir-2276-5p ; hsa-mir-6892-3p
Nearest miRNA
hsa-mir-101-2/Upstream/2078869; hsa-let-7a-1/Downstream/61290;
Nearest TSS
ENST00000422679/Upstream/7824; ENST00000463897/Downstream/16153;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/56101, chr9-CpG: 140/Downstream/57167
Upstream sequence
GCTGACTCCCTGCTATTCAGCAGCCTGCACTCTACTCCAGGAGGAACTGCACGGTCTATAGACAGCACCAAGAGTAGGAGTCGGGATGGAAGAGGCCCTG
Downstream sequence
GAGCCCCCAAACGACACAACCCCTTCTTGCTGCAGGAGGGTGTGGGTGAGCCAGGACTTGGTGACCTGTATGATGACAGCATTGGTGACAGTGCCACCCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate