Basic Information
VIS ID
TVIS44009611
Fusion event
HTLV-1-GNAQ integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
80507934/77893018 (Hg38)
End
80507934/77893018 (Hg38)
Orient
+
Location type
Intronic
Target gene
GNAQ
miRNAs that regulate target gene
hsa-mir-142-3p ; hsa-mir-128-3p ; hsa-mir-21-5p ; hsa-mir-5589-3p ; hsa-mir-653-5p ; hsa-mir-363-3p ; hsa-mir-367-3p ; hsa-mir-92b-3p ; hsa-mir-32-5p ; hsa-mir-25-3p ; hsa-mir-92a-3p ; hsa-mir-5579-3p ; hsa-mir-3613-3p ; hsa-mir-501-5p ; hsa-mir-500a-5p ; hsa-mir-4668-3p ; hsa-mir-129-5p ; hsa-mir-6885-3p ; hsa-mir-767-5p ; hsa-mir-3130-3p ; hsa-mir-3653-3p ; hsa-mir-3658 ; hsa-mir-4511 ; hsa-mir-548b-3p ; hsa-mir-4775 ; hsa-mir-590-3p
Nearest miRNA
hsa-mir-101-2/Upstream/7082934; hsa-let-7a-1/Downstream/6076730;
Nearest TSS
ENST00000422679/Upstream/244711; ENST00000536374/Downstream/137586;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/244233, chr9-CpG: 181/Downstream/137912
Nearest cancer related gene
GNAQ(OG, No orient, 0)
Upstream sequence
TGGGTGGAATATATGCATATTTGAATGTAGTAGGTAAGATAACTCTATCAAAATGTCAAAGGGTTTTATTGTTCCATCCATTACTTAATTATCTAAGGGT
Downstream sequence
AAACTGCCCACTTTATGGATAATCTACTAGGCTTGGAAAGCTTCAACAGGGTCATGAtgtcaaagggtttcaaaccagagcgactccatcttgaagtcac
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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