Basic Information
VIS ID
TVIS44009633
Fusion event
HTLV-1-DIAPH2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
95946662/96691663 (Hg38)
End
95946662/96691663 (Hg38)
Orient
+
Location type
Intronic
Target gene
DIAPH2
miRNAs that regulate target gene
hsa-mir-10b-5p ; hsa-mir-17-3p ; hsa-mir-4520-3p ; hsa-mir-4520-2-3p ; hsa-mir-20a-5p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-4473 ; hsa-mir-4671-3p ; hsa-mir-4778-3p ; hsa-mir-520f-3p ; hsa-mir-302c-3p ; hsa-mir-512-3p ; hsa-mir-641 ; hsa-mir-3617-5p
Nearest miRNA
hsa-let-7f-2/Upstream/1628437; hsa-mir-105-1/Downstream/9948151;
Nearest TSS
ENST00000429181/Upstream/6646; ENST00000373040/Downstream/192245;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/6296, chrX-CpG: 23/Downstream/3247673
Upstream sequence
TGAATTCTGGTATTTAACTGACTTTGTGTGAGGTTACCTGGCAGGGAAAGGTATTGGTCCCTTTCTCATGAAAGAATGTAGAAAACAAAATTCTTACTTA
Downstream sequence
TCACCATTTGCACAGTCTTTGGTTTACTGAAGATTTTACTGTATTGCTTTAAGGAGAGTAAGCTACATTGCTACAAATACATACCAGCATATTGGCCACC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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