Basic Information
VIS ID
TVIS44009639
Fusion event
HTLV-1-ATP11C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q27.1
Reference genome
GRCh37/hg19
Start
139007622/139925463 (Hg38)
End
139007622/139925463 (Hg38)
Orient
+
Location type
Intronic
Target gene
ATP11C
miRNAs that regulate target gene
hsa-mir-210-3p ; hsa-mir-9-5p ; hsa-mir-652-3p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-4705 ; hsa-mir-3074-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-154-3p ; hsa-mir-487a-3p
Nearest miRNA
hsa-let-7f-2/Upstream/1232; hsa-mir-105-1/Downstream/1000697;
Nearest TSS
ENST00000429181/Upstream/93175; ENST00000417426/Downstream/7607;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/232949, chrX-CpG: 154/Downstream/6240
Nearby gene
MIR505(-1232) ;
Upstream sequence
caacctctgcctcccaggttcaagtgattctcccgcctcagcctctcaagtagctgggattacaggcctgtgctaccactcctggctaattttGTAGCCC
Downstream sequence
AGTCTGAAATGCATAAGCTTCTTGGTGGCTGCTTCCTAAACTGATCATTCTTCATCTGTTATTACTGACTCAGACTGTGTTACCAATTCAGCTCAAAACA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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