Basic Information
VIS ID
TVIS44009654
Fusion event
HTLV-1-MIR7853 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
133874588/133117015 (Hg38)
End
133874588/133117015 (Hg38)
Orient
-
Location type
ncRNA_intronic
Fragile sites / regions
FRA2S
Target gene
MIR7853
Nearest miRNA
hsa-mir-1285-2/Upstream/683195; hsa-mir-10b/Downstream/1010110;
Nearest TSS
ENST00000437798/Upstream/201458; ENST00000454699/Downstream/147953;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/445718, chr2-CpG: 52/Downstream/149360
Upstream sequence
aaggccagtgctcaataatattagctcACTTGTTCTTTTGTAGACAACATACATAGAAGacagtatgaataatggttaagacctagggtatctgagttca
Downstream sequence
tacaacagctacaatacatccaagcagtatgaagatgggcaagttatttaactcatgggagcctcagtttcctcatctgtaaaggagagaggctaagaat
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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