Basic Information
VIS ID
TVIS44009671
Fusion event
HTLV-1-ABCC9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
21980002/21827068 (Hg38)
End
21980002/21827068 (Hg38)
Orient
+
Location type
Intronic
Target gene
ABCC9
miRNAs that regulate target gene
hsa-mir-142-3p ; hsa-mir-4668-5p ; hsa-mir-514b-3p ; hsa-mir-514a-3p ; hsa-mir-3978 ; hsa-mir-6124 ; hsa-mir-3148 ; hsa-mir-890 ; hsa-mir-4511 ; hsa-mir-3133
Nearest miRNA
hsa-mir-1244-3/Upstream/4153674; hsa-let-7i/Downstream/2385353;
Nearest TSS
ENST00000382841/Upstream/51487; ENST00000539874/Downstream/142;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/52011, chr12-CpG: 90/Downstream/113952
Upstream sequence
GTAACAAATGCATTACAAAGTAACCAAATGAATGGCCTGTTCTGCCCTTCCTGTTTCAGGTGTCAGTATTTTGTTTTTTGCAGGTGGAATTCAAGATACA
Downstream sequence
GAGTCTATTATATTTAGACAGGTTCAACTGCTTTTTCACGTGGGGGTTAAAGTATTGGGTTATGAGACAAACTAAACTAAACAATTTTGAGTTTGGCTGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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