Basic Information
VIS ID
TVIS44009676
Fusion event
HTLV-1-DNAJC16 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.21
Reference genome
GRCh37/hg19
Start
15883599/15557104 (Hg38)
End
15883599/15557104 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
DNAJC16
miRNAs that regulate target gene
hsa-mir-421 ; hsa-let-7c-5p ; hsa-mir-21-5p ; hsa-mir-578 ; hsa-mir-526b-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-3934-3p ; hsa-mir-6778-3p ; hsa-mir-4252 ; hsa-mir-627-3p ; hsa-mir-3124-3p ; hsa-mir-767-3p ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-6832-3p ; hsa-mir-1273g-3p
Nearest miRNA
hsa-mir-12136/Upstream/2978081; hsa-mir-101-1/Downstream/1301845;
Nearest TSS
ENST00000473358/Upstream/30291; ENST00000479655/Downstream/2504;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/29936, chr1-CpG: 62/Downstream/27489
Upstream sequence
taaacctaacttgcactcatgaaataaatccaacaagattatgatttctattatgctttcaatatattgctggattccatttgctaacattttgcttagg
Downstream sequence
actttgacattcatgttcagaaatgagattgacttctaacttttccttatcgtgatacccatgtGTTGCTTTTTCTCTTCTCAGGAAGACTTTATGTGAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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