Basic Information
VIS ID
TVIS44009678
Fusion event
HTLV-1-MTF1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p34.3
Reference genome
GRCh37/hg19
Start
38285659/37819987 (Hg38)
End
38285659/37819987 (Hg38)
Orient
+
Location type
Intronic
Target gene
MTF1
miRNAs that regulate target gene
hsa-mir-590-3p ; hsa-mir-103a-3p ; hsa-mir-32-5p ; hsa-mir-125b-5p ; hsa-mir-106a-5p ; hsa-mir-17-5p ; hsa-mir-337-3p ; hsa-mir-190a-3p ; hsa-mir-4789-5p ; hsa-mir-5011-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-384 ; hsa-mir-3685 ; hsa-mir-202-5p ; hsa-mir-8485 ; hsa-mir-3978 ; hsa-mir-3924 ; hsa-mir-3941 ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-548l ; hsa-mir-2054 ; hsa-mir-526a ; hsa-mir-523-5p ; hsa-mir-522-5p ; hsa-mir-520c-5p ; hsa-mir-519c-5p ; hsa-mir-519b-5p ; hsa-mir-519a-5p ; hsa-mir-518f-5p ; hsa-mir-518e-5p ; hsa-mir-518d-5p ; hsa-mir-6879-3p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-520g-5p ; hsa-mir-3620-3p ; hsa-mir-6865-3p ; hsa-mir-5007-5p ; hsa-mir-548an ; hsa-mir-643 ; hsa-mir-92a-3p ; hsa-mir-92b-3p ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p
Nearest miRNA
hsa-mir-12136/Upstream/318993; hsa-mir-101-1/Downstream/269244;
Nearest TSS
ENST00000473358/Upstream/11802; ENST00000419993/Downstream/38552;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/11257, chr1-CpG: 64/Downstream/39491
Upstream sequence
gttgcagtgagccaaaactgcaccactgcactccagcctaggcaacagagcaagactctgactcaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaGG
Downstream sequence
AGAAGTGAGACCCTAAATATCTGAAAAGAAAATGGATGACTTGTTTCACTCAGCACCCCAGGACAGGGCCAGAGAAAACAATAAAAACCACATGGAGGCG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate