Basic Information
VIS ID
TVIS44009700
Fusion event
HTLV-1-CACNB2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p12.33
Reference genome
GRCh37/hg19
Start
18497847/18208918 (Hg38)
End
18497847/18208918 (Hg38)
Orient
+
Location type
Intronic
Target gene
CACNB2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-16-5p ; hsa-mir-640 ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-378a-5p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-4680-5p ; hsa-mir-4635 ; hsa-mir-3653-5p ; hsa-mir-5193 ; hsa-mir-4667-3p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-6865-3p ; hsa-mir-4260 ; hsa-mir-5572 ; hsa-mir-450a-2-3p ; hsa-mir-6857-5p ; hsa-mir-6763-5p ; hsa-mir-3150a-3p ; hsa-mir-6810-5p ; hsa-mir-2110 ; hsa-mir-19b-2-5p ; hsa-mir-19b-1-5p ; hsa-mir-19a-5p ; hsa-mir-4450 ; hsa-mir-2052 ; hsa-mir-186-3p ; hsa-mir-8087 ; hsa-mir-7161-5p ; hsa-mir-548u ; hsa-mir-208a-3p ; hsa-mir-208b-3p
Nearest miRNA
hsa-mir-1265/Upstream/363725; hsa-mir-107/Downstream/2343052;
Nearest TSS
ENST00000439456/Upstream/67960; ENST00000498816/Downstream/51851;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/67627, chr10-CpG: 24/Downstream/442681
Upstream sequence
ACGACGTTTAGAGAGAGAAAGCCCCTGAACACGTATTAATTCTAAAGAATTCTAAGGAACTGATGCGTATACATCCACATATGAACCCAGGGCGATGTTG
Downstream sequence
AGTTCTTCTGGTGGGATTCTCTGGAGCACATCATCGTTGGCATTTGATGACTGTAAAATCGCTGGAAGTTGAATGTGCACATTTAAATAGAAACTAAATG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate