Basic Information
VIS ID
TVIS44009701
Fusion event
HTLV-1-NEBL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p12.31
Reference genome
GRCh37/hg19
Start
21444587/21155658 (Hg38)
End
21444587/21155658 (Hg38)
Orient
-
Location type
Intronic
Target gene
NEBL
miRNAs that regulate target gene
hsa-mir-125b-5p ; hsa-mir-7856-5p ; hsa-mir-4477b ; hsa-mir-4684-5p ; hsa-mir-6892-5p ; hsa-mir-942-5p ; hsa-mir-7845-5p ; hsa-mir-4475 ; hsa-mir-6507-3p ; hsa-mir-6883-3p ; hsa-mir-3156-3p ; hsa-mir-324-5p ; hsa-mir-3162-3p ; hsa-mir-4301 ; hsa-mir-140-3p
Nearest miRNA
hsa-mir-1265/Upstream/603612; hsa-mir-107/Downstream/340904;
Nearest TSS
ENST00000439456/Upstream/9099; ENST00000417845/Downstream/16794;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/1337641, chr10-CpG: 149/Downstream/17541
Upstream sequence
ttcactttatacataagtacttcGGAAATCTTGAGTACTGTGCCTATAATAAGGTAACATTTCAACTTTCAAACTCACATTCAAAACCCAAGTAATCACT
Downstream sequence
GGTAATCACTGCATTGCTACAGCTCAAACAATTGACACACCTGAAAAGACCAGAAGAGTGAAATAGGGAAAACATTACCTGGTTCCAGAGAGAAAACTGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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