Basic Information
VIS ID
TVIS44009705
Fusion event
HTLV-1-IPMK integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
59958123/58198362 (Hg38)
End
59958123/58198362 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10C
Target gene
IPMK
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-339-5p ; hsa-mir-1183 ; hsa-mir-6073 ; hsa-mir-6124 ; hsa-mir-20b-3p ; hsa-mir-4280 ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125 ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548au-5p ; hsa-mir-548as-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p ; hsa-mir-583 ; hsa-mir-1276 ; hsa-mir-4311 ; hsa-mir-548g-3p ; hsa-mir-548n ; hsa-mir-142-3p ; hsa-mir-921 ; hsa-mir-3606-5p ; hsa-mir-1257 ; hsa-mir-4790-3p ; hsa-mir-203a-3p ; hsa-mir-8067 ; hsa-mir-6508-5p ; hsa-mir-454-3p ; hsa-mir-3666 ; hsa-mir-4295 ; hsa-mir-301b-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-130a-3p ; hsa-mir-5680 ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p
Nearest miRNA
hsa-mir-1265/Upstream/893803; hsa-mir-107/Downstream/5174595;
Nearest TSS
ENST00000439456/Upstream/1837087; ENST00000489785/Downstream/69572;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/91325, chr10-CpG: 188/Downstream/68885
Upstream sequence
TATATTATTGAAAATTGAGACCTTTAAATGTTTTAACCTATCAGATTATTAGGCCTTTTTAAAAACTATGCCTATTTTATCATACTTGGGAATTTATAGG
Downstream sequence
TATATATAATTTGATTTCTGCTTTCAAATAACTTGTTCCCCCAATTTGGGACAGAAACTATTAAAAGATATATTCAGATATGACTAAATTATTAGCCTGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate