Basic Information
VIS ID
TVIS44009708
Fusion event
HTLV-1-TSG101 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
18542983/18521436 (Hg38)
End
18542983/18521436 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11C ; FRA11I
Target gene
TSG101
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-93-5p ; hsa-mir-33a-5p ; hsa-mir-20a-5p ; hsa-mir-17-5p ; hsa-mir-331-3p ; hsa-mir-106b-5p ; hsa-mir-3679-5p ; hsa-mir-1185-5p ; hsa-mir-6847-5p ; hsa-mir-4676-5p ; hsa-mir-575 ; hsa-mir-4797-5p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-548e-5p ; hsa-mir-106a-5p ; hsa-mir-526b-3p ; hsa-mir-20b-5p ; hsa-mir-519d-3p ; hsa-mir-181d-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-181a-5p
Nearest miRNA
hsa-mir-210/Upstream/133576; hsa-let-7a-2/Downstream/1053874;
Nearest TSS
ENST00000527297/Upstream/6586; ENST00000511927/Downstream/5385;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/65227, chr11-CpG: 52/Downstream/5077
Nearest cancer related gene
TSG101(TSG, No orient, 0)
Upstream sequence
caatatttgaccaaactgattcctttttttttttttttttttttttttttgagatagggtctcactctgtcgctcaggctacagtgcagtggtatgatca
Downstream sequence
tggctcacttcagcctcaacctcctggactcaagtgatactcccaccaccgcctcccaagtagctgggactacaggcatgcaccatcacacctggataat
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate