Basic Information
VIS ID
TVIS44009716
Fusion event
HTLV-1-POU2F3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
120119093/120248384 (Hg38)
End
120119093/120248384 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11B
Target gene
POU2F3
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-26b-5p ; hsa-mir-3620-5p ; hsa-mir-1587 ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-4741 ; hsa-mir-4675 ; hsa-mir-762 ; hsa-mir-5001-5p ; hsa-mir-4498 ; hsa-mir-4492 ; hsa-mir-6829-5p ; hsa-mir-4656 ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-6081 ; hsa-mir-3135b ; hsa-mir-661 ; hsa-mir-378g ; hsa-mir-766-3p ; hsa-mir-939-3p ; hsa-mir-6849-3p ; hsa-mir-508-5p ; hsa-mir-3679-3p ; hsa-mir-5681b ; hsa-mir-6832-3p ; hsa-mir-4252 ; hsa-mir-4793-3p ; hsa-mir-1273g-3p ; hsa-mir-7977 ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-4755-3p ; hsa-mir-342-3p ; hsa-mir-1972 ; hsa-mir-5685 ; hsa-mir-4690-3p ; hsa-mir-1228-3p ; hsa-mir-5694 ; hsa-mir-3675-3p ; hsa-mir-4293 ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4684-5p ; hsa-mir-4768-3p ; hsa-mir-548c-3p ; hsa-mir-6771-3p
Nearest miRNA
hsa-mir-10392/Upstream/935372; hsa-let-7a-2/Downstream/1851373;
Nearest TSS
ENST00000527297/Upstream/8123; ENST00000606153/Downstream/17548;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/8205, chr11-CpG: 68/Downstream/76712
Nearest cancer related gene
POU2F3(TSG, No orient, 0)
Upstream sequence
agaatcaaacagacctgggataaaatttgcagctccactgcttactggctgcatgacctgaaaatttatccttgtcccttttgtaaagggggaaaagtaa
Downstream sequence
tgcccaacttagagagtgggttgagagttacttgagatgatgtctcaagcccttagcacagtgcttggcacatggcaGCTGTGATCGTCATTAAGATTCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate