Basic Information
VIS ID
TVIS44009719
Fusion event
HTLV-1-SLC37A2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
124935396/125065500 (Hg38)
End
124935396/125065500 (Hg38)
Orient
+
Location type
Intronic
Target gene
SLC37A2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-2467-3p ; hsa-mir-3197 ; hsa-mir-4673 ; hsa-mir-4645-5p ; hsa-mir-4692 ; hsa-mir-6847-5p ; hsa-mir-4514 ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-4695-5p ; hsa-mir-584-3p ; hsa-mir-211-3p ; hsa-mir-1972 ; hsa-mir-7845-5p ; hsa-mir-3156-5p ; hsa-mir-1304-3p ; hsa-mir-181b-2-3p ; hsa-mir-181b-3p ; hsa-mir-3065-3p ; hsa-mir-383-3p ; hsa-mir-4286 ; hsa-mir-4291 ; hsa-mir-4329 ; hsa-mir-4420 ; hsa-mir-4786-5p ; hsa-mir-6849-3p ; hsa-mir-6871-3p ; hsa-mir-6872-3p ; hsa-mir-769-5p
Nearest miRNA
hsa-let-7a-2/Upstream/1683988; hsa-mir-3167/Downstream/1922958;
Nearest TSS
ENST00000527297/Upstream/2164; ENST00000525837/Downstream/17639;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/1739, chr11-CpG: 37/Downstream/45923
Upstream sequence
ttttaaagcctttaattatttattgtcctgacattagtaagccgagtcaagaaactgtcttcaccaggttttacctactgtactgatgtatttgggcaaa
Downstream sequence
ttcctcttctcagggtccccataatatcctaaagtttctgggctagccagagagtgaccttccttttggcttgtaaacctggaaacccagtaagcccatt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate