Basic Information
VIS ID
TVIS44009751
Fusion event
HTLV-1-CHURC1-FNTB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
65439879/64973161 (Hg38)
End
65439879/64973161 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA14B
Target gene
CHURC1-FNTB
Nearest miRNA
hsa-mir-208a/Upstream/187475; hsa-mir-1185-1/Downstream/71527;
Nearest TSS
ENST00000550708/Upstream/226; ENST00000555372/Downstream/65;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/516, chr14-CpG: 58/Downstream/13508
Upstream sequence
AGAATGAATGGCCCTTGTTCAAGATCCAGTTTCCTACCACTGAATGTGTTAGCACCGGAGAGAGGCAAATGAATGCTCTCCGGAGTTGAGAAAATTGCCT
Downstream sequence
ATCCCTACCAACGAGTATTGAGGGAGAGCAAAGTCTAGCCTATTAGGTCTTTAAAAAGCAATGAAAggctaggcgcgttggctcatgcctgtaatcccag
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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