Basic Information
VIS ID
TVIS44009760
Fusion event
HTLV-1-BFAR integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.12
Reference genome
GRCh37/hg19
Start
14734842/14640985 (Hg38)
End
14734842/14640985 (Hg38)
Orient
-
Location type
Intronic
Target gene
BFAR
miRNAs that regulate target gene
hsa-mir-29c-3p ; hsa-mir-103a-3p ; hsa-mir-98-5p ; hsa-mir-16-5p ; hsa-mir-92a-3p ; hsa-mir-5587-5p ; hsa-mir-203b-3p ; hsa-mir-7158-3p ; hsa-mir-323a-5p ; hsa-mir-6801-5p ; hsa-mir-4483 ; hsa-mir-1293 ; hsa-mir-4680-5p ; hsa-mir-4635 ; hsa-mir-6823-5p ; hsa-mir-34a-5p
Nearest miRNA
hsa-mir-1225/Upstream/331614; hsa-mir-11401/Downstream/260523;
Nearest TSS
ENST00000527434/Upstream/7822; ENST00000564078/Downstream/3303;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/7476, chr16-CpG: 21/Downstream/53235
Upstream sequence
AATTCAGACTTCCCGAGGCATCTCTCCAGATACCAGTTGTAGACCCAACTTTTTATTCAGAAACCTTAGCTCTTCAGAGTGACTCAGTGCCTATGGGAAC
Downstream sequence
TCCTGAGGTTTTGCTGTCCTCTTCAGTTCTAAGGTGTTCAGTCTATGGTTTTAAACTTGTTTGTTTGCTGTTTTGTAGATTTTTCCAAACCCAGTCATTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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