Basic Information
VIS ID
TVIS44009775
Fusion event
HTLV-1-RAB31 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
p11.22
Reference genome
GRCh37/hg19
Start
9844062/9844065 (Hg38)
End
9844062/9844065 (Hg38)
Orient
+
Location type
Intronic
Target gene
RAB31
miRNAs that regulate target gene
hsa-mir-140-3p ; hsa-mir-124-3p ; hsa-mir-196a-5p ; hsa-mir-30e-3p ; hsa-mir-30d-3p ; hsa-mir-30a-3p ; hsa-mir-6509-5p ; hsa-mir-487b-5p ; hsa-mir-487a-5p ; hsa-mir-4276 ; hsa-mir-331-5p ; hsa-mir-3117-5p ; hsa-mir-493-3p ; hsa-mir-5190 ; hsa-mir-425-5p ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p ; hsa-mir-5688 ; hsa-mir-495-3p ; hsa-mir-548an ; hsa-mir-297 ; hsa-mir-1229-3p ; hsa-mir-197-3p ; hsa-mir-567 ; hsa-mir-6862-3p ; hsa-mir-6784-3p ; hsa-mir-6511b-3p ; hsa-mir-6511a-3p ; hsa-mir-6834-3p ; hsa-mir-1255b-2-3p
Nearest miRNA
hsa-mir-3976/Upstream/3469640; hsa-mir-1-2/Downstream/915519;
Nearest TSS
ENST00000575820/Upstream/29344; ENST00000580795/Downstream/5531;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/134751, chr18-CpG: 175/Downstream/69402
Upstream sequence
TGGGGCAGGTGGAGGAAGGGGCGGGGAGGTGGGCGCTCTCCCATCACTCTCTGTCCCTGTTTTGATTTTGTGTCTTCCTTCTCTTTTCCAATAGCAATCC
Downstream sequence
TTCTGGTCGAGGATTGTGATACTCTTGCCTGCAGCATTAGAGGAGCTTCCAGATTCTTCTCCTCACCTCCATCCATTCTATGCACCATTTTTTCCTAGAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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