Basic Information
VIS ID
TVIS44009779
Fusion event
HTLV-1-PIAS2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
44441998/46862035 (Hg38)
End
44441998/46862035 (Hg38)
Orient
+
Location type
Intronic
Target gene
PIAS2
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-3658 ; hsa-mir-3653-3p ; hsa-mir-4720-3p ; hsa-mir-6507-5p ; hsa-mir-6126 ; hsa-mir-3140-3p ; hsa-mir-4493 ; hsa-mir-605-3p ; hsa-mir-497-3p ; hsa-mir-498 ; hsa-mir-4279 ; hsa-mir-4713-5p ; hsa-mir-23b-5p ; hsa-mir-23a-5p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-2116-3p ; hsa-mir-532-3p ; hsa-mir-150-5p ; hsa-mir-6742-3p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-1281 ; hsa-mir-1343-3p ; hsa-mir-4485-5p ; hsa-mir-660-3p ; hsa-mir-6783-3p ; hsa-mir-6791-3p ; hsa-mir-6829-3p ; hsa-mir-6852-5p ; hsa-mir-939-3p ; hsa-mir-129-5p ; hsa-mir-1303 ; hsa-mir-1304-3p ; hsa-mir-133a-3p ; hsa-mir-133b ; hsa-mir-215-3p ; hsa-mir-3664-5p ; hsa-mir-4639-3p ; hsa-mir-5007-5p ; hsa-mir-6758-5p ; hsa-mir-6773-3p ; hsa-mir-6794-3p ; hsa-mir-6843-3p ; hsa-mir-6848-3p ; hsa-mir-6856-5p ; hsa-mir-6879-3p
Nearest miRNA
hsa-mir-1-2/Upstream/1891869; hsa-mir-122/Downstream/518461;
Nearest TSS
ENST00000575820/Upstream/17064; ENST00000585383/Downstream/2197;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/103898, chr18-CpG: 126/Downstream/54912
Upstream sequence
attgtactatggtgatataagatttaatattaaaggaaacagggataaagaatatatgtattatttctataatttttatctaaataaaaattactacaaa
Downstream sequence
atataaagttTTTATgccgggcatggtggctcacgcctgtaatcccagcactttgggaggccgaacaggtggatcacttgaggccaggagttcaagacaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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