Basic Information
VIS ID
TVIS44009798
Fusion event
HTLV-1-TYW5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
200798000/199933277 (Hg38)
End
200798000/199933277 (Hg38)
Orient
+
Location type
Exonic
Fragile sites / regions
FRA2I
Target gene
TYW5
miRNAs that regulate target gene
hsa-mir-93-5p ; hsa-mir-3144-3p ; hsa-mir-4266 ; hsa-mir-4495 ; hsa-mir-875-5p ; hsa-mir-6888-5p ; hsa-mir-1179 ; hsa-mir-1252-3p ; hsa-mir-3646 ; hsa-mir-129-5p ; hsa-mir-505-3p ; hsa-mir-3121-5p
Nearest miRNA
hsa-mir-10b/Upstream/10800166; hsa-mir-1244-1/Downstream/6849957;
Nearest TSS
ENST00000437798/Upstream/21971; ENST00000469156/Downstream/22040;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/21452, chr2-CpG: 61/Downstream/22053
Upstream sequence
CAGAATTTGTGCAGCTCTTGATGCTGCTGTAGGATCTTTGTTTCCATAGGTATCTGTTTTATCATAGCATTCAGATGGAAGGTGCTTCCAAAAGATATTC
Downstream sequence
ACTCCCACTCCAAACTCTTCAGAAATTACATTATGGAACCATAAAGCTGGAGAAAGTTTAAAAAACAAGTTAAAAATAAAACCTACAGTTAAAAAAAAAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate