Basic Information
VIS ID
TVIS44009799
Fusion event
HTLV-1-GPR55 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q37.1
Reference genome
GRCh37/hg19
Start
231803761/230939046 (Hg38)
End
231803761/230939046 (Hg38)
Orient
+
Location type
Intronic
Target gene
GPR55
miRNAs that regulate target gene
hsa-mir-92b-3p ; hsa-mir-18a-3p ; hsa-mir-16-5p ; hsa-mir-1238-3p ; hsa-mir-670-3p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-6826-3p ; hsa-mir-24-3p ; hsa-mir-1236-3p ; hsa-mir-877-3p ; hsa-mir-4667-3p ; hsa-mir-6795-3p ; hsa-mir-6887-3p ; hsa-mir-6749-3p ; hsa-mir-6787-3p ; hsa-mir-660-3p ; hsa-mir-2355-5p ; hsa-mir-3157-5p ; hsa-mir-4286 ; hsa-mir-4691-3p ; hsa-mir-3620-3p ; hsa-mir-675-5p
Nearest miRNA
hsa-mir-10b/Upstream/3466859; hsa-mir-1244-1/Downstream/423662;
Nearest TSS
ENST00000437798/Upstream/13820; ENST00000454918/Downstream/22020;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/72940, chr2-CpG: 27/Downstream/48085
Nearby gene
GPR55(-13820) ;
Upstream sequence
CACTTCAAGAAGAAAGTCAGCTGCAGCATGGCTCCCACCTCGCCGCCTGGGGCATGGAAGCATCTAGCACAGAGGGCTCCTGCCGTGTGGCCAGTTCTCG
Downstream sequence
AGATGGAGACTGAAGAGGCCGACTAGCCAACAATGAGCACTCGCCGCAACCTACCCTAGACTTCTCCTTTGTCCCTGCAGCCCTGGGGCCTAGGCTGAGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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