Basic Information
VIS ID
TVIS44009807
Fusion event
HTLV-1-EP300 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr22
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
41557951/41161947 (Hg38)
End
41557951/41161947 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
EP300
miRNAs that regulate target gene
hsa-mir-200c-3p ; hsa-mir-200b-3p ; hsa-mir-429 ; hsa-mir-182-5p ; hsa-mir-194-5p ; hsa-mir-26b-5p ; hsa-mir-374a-5p ; hsa-mir-150-5p ; hsa-mir-9-5p ; hsa-mir-130b-5p ; hsa-mir-615-3p ; hsa-mir-181d-5p ; hsa-mir-193b-3p ; hsa-mir-149-5p ; hsa-mir-140-5p ; hsa-mir-23b-3p ; hsa-mir-181b-5p ; hsa-mir-30c-5p ; hsa-mir-92a-3p ; hsa-mir-30a-3p ; hsa-mir-25-3p ; hsa-let-7b-5p ; hsa-mir-574-3p ; hsa-mir-6818-5p ; hsa-mir-6867-5p ; hsa-mir-574-5p ; hsa-mir-4433b-3p ; hsa-mir-7109-5p ; hsa-mir-4758-5p ; hsa-mir-1238-5p ; hsa-mir-4472 ; hsa-mir-4447 ; hsa-mir-6885-5p ; hsa-mir-328-5p ; hsa-mir-6887-5p ; hsa-mir-6795-5p ; hsa-mir-4481 ; hsa-mir-4745-5p ; hsa-mir-1296-3p ; hsa-mir-129-5p ; hsa-mir-1297 ; hsa-mir-1305 ; hsa-mir-26a-5p ; hsa-mir-3173-3p ; hsa-mir-4428 ; hsa-mir-4465 ; hsa-mir-498 ; hsa-mir-555 ; hsa-mir-595 ; hsa-mir-6755-5p ; hsa-mir-6835-5p ; hsa-mir-6841-5p ; hsa-mir-6885-3p ; hsa-mir-6891-5p
Nearest miRNA
hsa-mir-1281/Upstream/69381; hsa-let-7a-3/Downstream/91045;
Nearest TSS
ENST00000624155/Upstream/3479; ENST00000635584/Downstream/780;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/68792, chr22-CpG: 95/Downstream/35072
Upstream sequence
ATAGCAGTGTCTGGGTGCTAGCTAGGAGAGTAGATACTAGGAGCCTTTGATCCTTGAAACATTTTGACATTTGGTTAAGCCAGGAAGGTTAGCTCTAGGG
Downstream sequence
TAAGTTTCCTTGATGCAGGAAGAGACGTAAGCCTTGTCATTGAACTCTCAGGTGGCTTACCAAATAGTCTAAACCTTAAGGCAGTACATCTCTAACTTTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate