VISDB - VIS Detail

Basic Information

VIS ID

TVIS44009819

Fusion event

HTLV-1-ARHGAP31 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr3

Cytoband

q13.33

Reference genome

GRCh37/hg19

Start

119050677/119331830 (Hg38)

End

119050677/119331830 (Hg38)

Orient

Location type

Intronic

Target gene

ARHGAP31

miRNAs that regulate target gene

hsa-mir-6770-3p ; hsa-mir-6825-5p ; hsa-mir-4730 ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-7106-5p ; hsa-mir-149-3p ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-663a ; hsa-mir-6787-5p ; hsa-mir-1908-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-765 ; hsa-mir-4706 ; hsa-mir-4749-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-6889-5p ; hsa-mir-6777-5p ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-6873-5p ; hsa-mir-6760-5p ; hsa-mir-3680-3p ; hsa-mir-576-5p ; hsa-mir-33b-5p ; hsa-mir-33a-5p ; hsa-mir-4735-5p ; hsa-mir-133a-5p ; hsa-mir-138-5p ; hsa-mir-3189-5p ; hsa-mir-3692-5p ; hsa-mir-4758-3p ; hsa-mir-544a ; hsa-mir-548q ; hsa-mir-5699-5p ; hsa-mir-6071 ; hsa-mir-6131 ; hsa-mir-6738-3p ; hsa-mir-6828-3p ; hsa-mir-93-3p

Nearest miRNA

hsa-let-7g/Upstream/2481463; hsa-mir-12124/Downstream/752734;

Nearest TSS

ENST00000440867/Upstream/6938; ENST00000390401/Downstream/104986;

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/8422, chr3-CpG: 24/Downstream/70170

Upstream sequence

TAACAAGGACAAAACAATTTTAGCAGGATTATGAAAATCAGGGCTGTCTTAAAGTTTgactcagaagaaacctcatagggcagctaatcccagcccaacc

Downstream sequence

cagtacaggaatcctggacccaggagtcatccagcttctgctcagcttctgcagggcctggctgcctgcaccgcctcactacacggcccattcccttagg

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.