Basic Information
VIS ID
TVIS44009820
Fusion event
HTLV-1-SRPRB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
133511023/133792179 (Hg38)
End
133511023/133792179 (Hg38)
Orient
-
Location type
Intronic
Target gene
SRPRB
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-92a-3p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-6838-5p ; hsa-mir-488-3p ; hsa-mir-3714 ; hsa-mir-548an ; hsa-mir-6760-5p ; hsa-mir-6878-5p ; hsa-mir-6892-5p ; hsa-mir-498 ; hsa-mir-4426 ; hsa-mir-4647 ; hsa-mir-4662b ; hsa-mir-5589-3p ; hsa-mir-6515-3p ; hsa-mir-8060 ; hsa-mir-510-3p ; hsa-mir-7153-5p ; hsa-mir-146b-5p ; hsa-mir-6730-5p ; hsa-mir-146a-5p ; hsa-mir-5681a ; hsa-mir-4475 ; hsa-mir-7155-3p ; hsa-mir-3136-3p ; hsa-mir-4699-5p ; hsa-mir-676-5p ; hsa-mir-4724-5p ; hsa-mir-578 ; hsa-mir-4642 ; hsa-mir-891b
Nearest miRNA
hsa-let-7g/Upstream/1806248; hsa-mir-1224/Downstream/575625;
Nearest TSS
ENST00000440867/Upstream/8146; ENST00000484684/Downstream/13436;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/8060, chr3-CpG: 53/Downstream/13545
Upstream sequence
tcataaaccgcttctttgacttttaaaaattgctcaatttattttggagcattagattctagataaggcctggggacaaatagaattagccatgtcccct
Downstream sequence
agctatgcaaagaaggttataaagaaaggagattttatataagaaaggatcttatatcgtaaattcgtgtcctaaagtaaaataagcggttgttaaaaaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate