Basic Information
VIS ID
TVIS44009830
Fusion event
HTLV-1-CCDC149 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
24948629/24947007 (Hg38)
End
24948629/24947007 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4D
Target gene
CCDC149
miRNAs that regulate target gene
hsa-mir-488-3p ; hsa-mir-6730-5p ; hsa-mir-5681a ; hsa-mir-4766-5p ; hsa-mir-651-3p ; hsa-mir-3133 ; hsa-mir-548b-3p ; hsa-mir-510-3p ; hsa-mir-4769-5p ; hsa-mir-4654 ; hsa-mir-6778-5p ; hsa-mir-1233-5p ; hsa-mir-4648 ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-494-3p ; hsa-mir-299-3p ; hsa-mir-4657 ; hsa-mir-4491 ; hsa-mir-8485 ; hsa-mir-6738-3p ; hsa-mir-5001-3p ; hsa-mir-4727-5p ; hsa-mir-6868-3p ; hsa-mir-4635 ; hsa-mir-1248 ; hsa-mir-1237-3p ; hsa-mir-466 ; hsa-mir-4672 ; hsa-mir-3941 ; hsa-mir-4796-5p ; hsa-mir-494-5p ; hsa-mir-410-5p ; hsa-mir-323b-5p ; hsa-mir-600 ; hsa-mir-26a-2-3p ; hsa-mir-26a-1-3p ; hsa-mir-6731-3p ; hsa-mir-3938 ; hsa-mir-4643 ; hsa-mir-4789-3p
Nearest miRNA
hsa-mir-12113/Upstream/426717; hsa-mir-1243/Downstream/3872575;
Nearest TSS
ENST00000502981/Upstream/34053; ENST00000510415/Downstream/33141;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/33752, chr4-CpG: 78/Downstream/83399
Upstream sequence
TCCTCTCCGAACTGTGAATTATTTCCTCTTTGTAATGCCATCTGCTTCCTCCACCCAAGCCACTTTACAATGCTTTCCTAAAGTCGATTTCAATAGCTTC
Downstream sequence
CTCTCTGCCCAGGAAAACAGGTTCCTGTGCAGGACAGTAATAATATTTTTGCAATCTTTGGATAAATTATGTTAATTTTCCCCCTTTATTAATTTACTAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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