Basic Information
VIS ID
TVIS44009837
Fusion event
HTLV-1-ADGRL3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q13.1
Reference genome
GRCh37/hg19
Start
62104072/61238354 (Hg38)
End
62104072/61238354 (Hg38)
Orient
+
Location type
Intronic
Target gene
ADGRL3
miRNAs that regulate target gene
hsa-mir-20a-5p
Nearest miRNA
hsa-mir-12113/Upstream/315670; hsa-mir-1243/Downstream/5038470;
Nearest TSS
ENST00000502981/Upstream/36212; ENST00000509089/Downstream/189867;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/35271, chr4-CpG: 60/Downstream/2110775
Nearby gene
ADGRL3(No orient, 258767)
Upstream sequence
AATTATTAAAATACTTATTCACTGTGGTACTACATTTTAACAAATTGAGGATTCACTTAAGATACAAATATTTTGAACTCCCTTATACTCTCTGTTATCT
Downstream sequence
CTATAAGGTTCTGTTTTCGAGGTTTATCTAAATACTTCATAGTGAAACTTAAACATTAGTTTTATTAAAGGGTAAATTCTAAtgtgtggtgtgtgtgtgt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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