Basic Information
VIS ID
TVIS44009840
Fusion event
HTLV-1-chr4 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
92539348/91618197 (Hg38)
End
92539348/91618197 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA4E
Nearest miRNA
hsa-mir-12113/Upstream/4317614; hsa-mir-1243/Downstream/7379190;
Nearest TSS
ENST00000502981/Upstream/292891; ENST00000505511/Downstream/269689;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/779081, chr4-CpG: 26/Downstream/564269
Nearby gene
CCSER1(No orient, 15978)
Upstream sequence
agaactcttgtacactgttggtgggaatgtaagttagtacattagtacatagtgactctcatggaaaacagtatggagatttcttacaaaactaaaaata
Downstream sequence
gaagttttatatgatctagcaatcctggtactggatatttatccaaaggaaaagaaatcagtgcatcaaaaagatacctgcacccacatgtttattgcat
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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