Basic Information
VIS ID
TVIS44009863
Fusion event
HTLV-1-POLH integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
43578962/43611225 (Hg38)
End
43578962/43611225 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
POLH
miRNAs that regulate target gene
hsa-mir-183-5p ; hsa-mir-135a-5p ; hsa-mir-135b-5p ; hsa-mir-2053 ; hsa-mir-3152-3p ; hsa-mir-3662 ; hsa-mir-383-3p ; hsa-mir-5197-5p ; hsa-mir-569 ; hsa-mir-8066
Nearest miRNA
hsa-mir-10398/Upstream/176605; hsa-mir-10524/Downstream/642981;
Nearest TSS
ENST00000381078/Upstream/19863; ENST00000508232/Downstream/10942;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/34886, chr6-CpG: 68/Downstream/17828
Upstream sequence
CTCTGGGAGAAAATACAGTACCAACCTCAGAAACAAGACAGCTCAGCACAGATCCTTTGCCGACAGCTGATACATTCCAGTTCCCAGGAGGTTAGACCCT
Downstream sequence
TACTCTGTATTGGCTTGGTCAGGGAAATGACCAGTTGCACTTGGAGAACAGAGCTCAAATTTCAAGGATACATTTGGGAACTTCAAACTACTTGATTGTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate