Basic Information
VIS ID
TVIS44009867
Fusion event
HTLV-1-UFL1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q16.1
Reference genome
GRCh37/hg19
Start
96971443/96523567 (Hg38)
End
96971443/96523567 (Hg38)
Orient
+
Location type
Intronic
Target gene
UFL1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-744-3p ; hsa-mir-1273e ; hsa-mir-203a-3p ; hsa-mir-382-5p ; hsa-mir-495-5p ; hsa-mir-335-3p ; hsa-mir-4762-3p ; hsa-mir-4256 ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-6719-3p ; hsa-mir-4526 ; hsa-mir-3660 ; hsa-mir-6730-3p
Nearest miRNA
hsa-mir-10398/Upstream/5001830; hsa-mir-1202/Downstream/1500964;
Nearest TSS
ENST00000381078/Upstream/1759; ENST00000450218/Downstream/38981;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1343, chr6-CpG: 83/Downstream/313387
Nearest cancer related gene
UFL1(TSG, No orient, 0)
Upstream sequence
TATAATTTAAATGAACTCAAATGTTGTCACTTAAAATATTTTATCATTTTGAGTTATGTGTACTATACATGAATTAATTGTTTCTTTTTACAATTCATTA
Downstream sequence
ATTTATTGCATGACTCAGGGAAGGGTATTCAGCTGCCTTTTATTAGGTGGTAATTGTGAAGGGGGACAGTATCTTACAGGATTATAGATTTTTGAAAATC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate