Basic Information
VIS ID
TVIS44009872
Fusion event
HTLV-1-VOPP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
55576663/55508970 (Hg38)
End
55576663/55508970 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7A
Target gene
VOPP1
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-320b ; hsa-mir-877-3p ; hsa-mir-324-3p ; hsa-mir-320a ; hsa-mir-15b-5p ; hsa-mir-431-5p ; hsa-mir-5581-3p ; hsa-mir-1273f ; hsa-mir-4708-5p ; hsa-mir-6088 ; hsa-mir-4770 ; hsa-mir-143-3p ; hsa-mir-1343-3p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-195-5p ; hsa-mir-374b-3p ; hsa-mir-424-5p ; hsa-mir-4524a-5p ; hsa-mir-4524b-5p ; hsa-mir-4690-3p ; hsa-mir-497-5p ; hsa-mir-503-5p ; hsa-mir-5685 ; hsa-mir-646 ; hsa-mir-6783-3p ; hsa-mir-6838-5p ; hsa-mir-938
Nearest miRNA
hsa-mir-1183/Upstream/10627170; hsa-mir-10399/Downstream/1446815;
Nearest TSS
ENST00000635602/Upstream/80914; ENST00000454777/Downstream/7107;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/59414, chr7-CpG: 144/Downstream/62614
Upstream sequence
gtctctataaaaaaatctttaaaattagccagacgtggtagcatatgcctatagtcctagcgactcagaggctgaggtgagaggatcgcttgagtcaagg
Downstream sequence
ggtttgaggctgcagtgagctagtactgcaccactgtgttccagcctaggtgacagagcaagaccctgtctcaaatttattatcaattttaattttataa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate