Basic Information
VIS ID
TVIS44009875
Fusion event
HTLV-1-LMTK2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
97763588/98134276 (Hg38)
End
97763588/98134276 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7F
Target gene
LMTK2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-615-3p ; hsa-mir-1277-5p ; hsa-mir-3149 ; hsa-mir-190a-3p ; hsa-mir-5011-5p ; hsa-mir-6513-5p ; hsa-mir-5089-5p ; hsa-mir-6728-5p ; hsa-mir-769-3p ; hsa-mir-450b-3p ; hsa-mir-6807-5p ; hsa-mir-3147 ; hsa-mir-4425 ; hsa-mir-1292-3p ; hsa-mir-411-5p ; hsa-mir-6832-5p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-4753-3p ; hsa-mir-3157-5p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-6758-3p ; hsa-mir-4691-3p ; hsa-mir-6875-3p ; hsa-mir-5706 ; hsa-mir-4782-5p ; hsa-mir-6749-3p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-4320 ; hsa-mir-6839-5p ; hsa-mir-378j ; hsa-mir-518c-5p ; hsa-mir-150-5p ; hsa-mir-1306-5p ; hsa-mir-216a-5p ; hsa-mir-4530 ; hsa-mir-7977
Nearest miRNA
hsa-mir-10525/Upstream/169795; hsa-mir-10399/Downstream/747374;
Nearest TSS
ENST00000635602/Upstream/7711; ENST00000314018/Downstream/77151;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/26867, chr7-CpG: 20/Downstream/37192
Upstream sequence
gagctggtcgtattacctcagaggtattgtgacagccaaatgaaataatgctgtattttatcaaatgtcagatgaggttgatgataagtcacacccttag
Downstream sequence
ttttgtaccattaaaaagaagaaatgctgccagttaagctaacttgaagtgtgagatgcacctgaaattcagagatgcagtggacaaactgtgtgtTATT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate