Basic Information
VIS ID
TVIS44009876
Fusion event
HTLV-1-IMMP2L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
110490234/110850178 (Hg38)
End
110490234/110850178 (Hg38)
Orient
-
Location type
Intronic
Target gene
IMMP2L
miRNAs that regulate target gene
hsa-mir-218-5p ; hsa-mir-587 ; hsa-mir-3180-5p ; hsa-mir-6515-5p ; hsa-mir-4443 ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-6815-3p ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-103a-2-5p ; hsa-mir-3188 ; hsa-mir-770-5p ; hsa-mir-4712-5p
Nearest miRNA
hsa-mir-10525/Upstream/8378647; hsa-mir-10399/Downstream/3803167;
Nearest TSS
ENST00000635602/Upstream/315424; ENST00000464835/Downstream/113387;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/2279716, chr7-CpG: 68/Downstream/711845
Upstream sequence
AGAGAATCAGTGAGAAAACTACTAAAGTCAGAAAATATAATGCATAATCAGAAAATAAATAAGAAAAAAGAGCTATATATCAGCAATTAGggtaggagac
Downstream sequence
tggtaggacttgttttctgctatcaaaacaggatctggtccatacaaaataaagcaaaaaaaccaagtaggaaccagcgatccctagctgccttcattgc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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