Basic Information
VIS ID
TVIS44009877
Fusion event
HTLV-1-TRIM24 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q34
Reference genome
GRCh37/hg19
Start
138256345/138571600 (Hg38)
End
138256345/138571600 (Hg38)
Orient
+
Location type
Intronic
Target gene
TRIM24
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-1-3p ; hsa-let-7b-5p ; hsa-mir-4477a ; hsa-mir-548at-5p ; hsa-mir-548ay-3p ; hsa-mir-548at-3p ; hsa-mir-548as-3p ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-330-3p ; hsa-mir-548aa ; hsa-mir-6835-3p ; hsa-mir-6807-5p ; hsa-mir-2355-5p ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-1292-3p ; hsa-mir-3934-5p ; hsa-mir-552-3p ; hsa-mir-511-5p ; hsa-mir-155-3p ; hsa-mir-3124-3p ; hsa-mir-3685 ; hsa-mir-384 ; hsa-mir-892c-5p
Nearest miRNA
hsa-mir-10525/Upstream/447779; hsa-mir-10399/Downstream/472500;
Nearest TSS
ENST00000635602/Upstream/16830; ENST00000472775/Downstream/54494;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/110322, chr7-CpG: 74/Downstream/92617
Nearest cancer related gene
TRIM24(TSG, No orient, 0)
Upstream sequence
gtgatggatcatggaatctaagctgggaaaggagaaaagtaaggacatggaaagatatgctgggacgttgaatggctggACATCAGAAGAGATGAAGACA
Downstream sequence
AGTTTAATAATAGAAATCCTGTTAGATCATACTGACAAGTGCAAAATTACCTCTGGTTTATACTACATGTAAATTAACTCACTCTCCAAACTCTTTGTCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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