Basic Information
VIS ID
TVIS44009887
Fusion event
HTLV-1-ARFGEF1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
68246729/67334494 (Hg38)
End
68246729/67334494 (Hg38)
Orient
-
Location type
Intronic
Target gene
ARFGEF1
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-877-3p ; hsa-mir-125a-3p ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-3692-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-1228-3p ; hsa-mir-424-3p ; hsa-mir-27b-5p ; hsa-mir-1254 ; hsa-mir-3116 ; hsa-mir-3690 ; hsa-mir-4638-3p ; hsa-mir-4793-3p ; hsa-mir-4797-5p ; hsa-mir-508-5p ; hsa-mir-5586-3p ; hsa-mir-6512-3p ; hsa-mir-6720-5p ; hsa-mir-6849-3p ; hsa-mir-759 ; hsa-mir-7703
Nearest miRNA
hsa-mir-124-1/Upstream/2955237; hsa-mir-10400/Downstream/7214049;
Nearest TSS
ENST00000518652/Upstream/62786; ENST00000607397/Downstream/9183;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/269281, chr8-CpG: 91/Downstream/8400
Upstream sequence
ttcatcataacaactaggatggctaaaaataaaaaggcagtaacaaatattggtgagaatttgaagaaacgggaagcctcatacactgctggtgggtatg
Downstream sequence
taggctggaaaagaatttagcagtttcttaaaaagttaaacataaatttatcaagtggcccaccaattcccttcccagtttgtctacctaggacaaataa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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