Basic Information
VIS ID
TVIS44009894
Fusion event
HTLV-1-SPATA6L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
4661960/4661960 (Hg38)
End
4661960/4661960 (Hg38)
Orient
+
Location type
Exonic
Target gene
SPATA6L
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-1302-9/Upstream/4631679; hsa-let-7a-1/Downstream/188337;
Nearest TSS
ENST00000422679/Upstream/89625; ENST00000381883/Downstream/355;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/170542, chr9-CpG: 66/Downstream/292
Upstream sequence
CTTCAGACAACAAAAGCCAATGAGAAAGTCAAGATCACCTTTTCAAATCTCATGCTCTCCTGAATCATAATGGGGAACGCAGAGGGAAAGCTGTTGGTCT
Downstream sequence
CCAGGTACTGATTCATGAGGTAGACCCCGAGGTACACATCTTGTTTGCCAGGCAGGAACACTCCTGGGCAAGAAATCTTAAAAAGAAAGAAAACAACAAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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