Basic Information
VIS ID
TVIS44009897
Fusion event
HTLV-1-MOB3B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
27377806/27377808 (Hg38)
End
27377806/27377808 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA9C
Target gene
MOB3B
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-122-5p ; hsa-mir-181a-5p ; hsa-mir-98-5p ; hsa-mir-4776-3p ; hsa-mir-192-3p ; hsa-mir-19b-2-5p ; hsa-mir-19b-1-5p ; hsa-mir-19a-5p ; hsa-mir-2052 ; hsa-mir-2114-5p ; hsa-mir-4307 ; hsa-mir-33a-3p ; hsa-mir-409-3p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-1227-3p ; hsa-mir-455-5p ; hsa-mir-148a-5p
Nearest miRNA
hsa-mir-101-2/Upstream/5865623; hsa-let-7a-1/Downstream/1485818;
Nearest TSS
ENST00000422679/Upstream/80669; ENST00000448858/Downstream/13926;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/421036, chr9-CpG: 27/Downstream/150551
Upstream sequence
GGCAACTGAACTGTGACCTATAAAAAGTTTTAAAAACTAGCGAAATGTTCTCTAAGACTTTCACATTTCCTCTGTAAAATTCAAATTCCGTTTGACATTC
Downstream sequence
TATTTAGGTTTGCCCCAGAGTAACACTGGCCAACTTTACAGAAGTGTGGATAGTGACGTTCATTTGAACCCTAGGTCCCCCACAGGGGGTTGAAGGGCAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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