Basic Information
VIS ID
TVIS44009899
Fusion event
HTLV-1-GNA14 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
80152603/77537687 (Hg38)
End
80152603/77537687 (Hg38)
Orient
+
Location type
Intronic
Target gene
GNA14
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-335-3p ; hsa-mir-5096 ; hsa-mir-197-3p ; hsa-mir-3941 ; hsa-mir-8064 ; hsa-mir-153-5p ; hsa-mir-6767-3p ; hsa-mir-603 ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-8485 ; hsa-mir-548c-3p
Nearest miRNA
hsa-mir-101-2/Upstream/6727603; hsa-let-7a-1/Downstream/6432061;
Nearest TSS
ENST00000422679/Upstream/81392; ENST00000536374/Downstream/110620;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/359275, chr9-CpG: 108/Downstream/109843
Upstream sequence
gattaatacctagtagtagattgctggattgtatggtaatctattttgagttgttggagaattctccatactgttttccatagtggttatattagtttac
Downstream sequence
attcccaccaacagtgtatgagttcccttttctctgcatccttgccagcatgtcattttttgtcttttagtagtagctattctaactagggaatggtagt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate