Basic Information
VIS ID
TVIS44009907
Fusion event
HTLV-1-PUDP integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p22.31
Reference genome
GRCh37/hg19
Start
6742864/6824823 (Hg38)
End
6742864/6824823 (Hg38)
Orient
+
Location type
Intronic
Target gene
PUDP
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-98-5p ; hsa-mir-346 ; hsa-mir-106a-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-3690-1/Upstream/440860; hsa-let-7f-2/Downstream/323037;
Nearest TSS
ENST00000429181/Upstream/103279; ENST00000217961/Downstream/323302;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/596958, chrX-CpG: 117/Downstream/322829
Nearby gene
PUDP(No orient, 224097)
Upstream sequence
tgccatttctcctattaatcaatctgcctcatgtcagttgcttttcagtgaacttccagggagccaaaggcaatggcccccacTTGGGCATATATAATGA
Downstream sequence
AAAATCAAATTTAAAATGTTGCCTTTTTAAAATTCACTAAATAAAAATAAACATGTTCAGGAAAGCAACTCTCCTATAACTTCAAAGAGCACCCAGGTGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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