Basic Information
VIS ID
TVIS44009917
Fusion event
HTLV-1-ERMP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
p24.1
Reference genome
GRCh37/hg19
Start
5791202/5791202 (Hg38)
End
5791202/5791202 (Hg38)
Orient
-
Location type
Intronic
Target gene
ERMP1
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-335-5p ; hsa-mir-125a-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-218-5p ; hsa-mir-4693-5p ; hsa-mir-223-5p ; hsa-mir-4720-3p ; hsa-mir-4804-3p ; hsa-mir-892a ; hsa-mir-4318 ; hsa-mir-4797-5p ; hsa-mir-429 ; hsa-mir-200c-3p ; hsa-mir-200b-3p
Nearest miRNA
hsa-mir-101-2/Upstream/940827; hsa-let-7a-1/Downstream/216624;
Nearest TSS
ENST00000422679/Upstream/20996; ENST00000490518/Downstream/41639;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/161459, chr9-CpG: 88/Downstream/41377
Upstream sequence
CAGCTGCAGGAACAGTTGAAGTGAACTTCCtatattagcattctccagggaaaccaacaggatgtgtacagagagaaagagagagagagacagagagagt
Downstream sequence
gattgagatttattttaaggaactggcttacatgattgttgaggctggcaagtccaaaatctgaaggataggcaggcaggctgaagaaaaaagtcacagt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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