Basic Information
VIS ID
TVIS44009929
Fusion event
HTLV-1-SELENOF integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
87328524/86862841 (Hg38)
End
87328524/86862841 (Hg38)
Orient
-
Location type
UTR3
Fragile sites / regions
FRA1D
Target gene
SELENOF
miRNAs that regulate target gene
hsa-mir-5585-3p ; hsa-mir-6794-3p ; hsa-mir-4693-5p ; hsa-mir-8065 ; hsa-mir-4635 ; hsa-mir-550b-3p ; hsa-mir-4661-3p ; hsa-mir-4639-3p ; hsa-mir-1183
Nearest miRNA
hsa-mir-101-1/Upstream/505154; hsa-mir-11399/Downstream/6983991;
Nearest TSS
ENST00000473358/Upstream/28672; ENST00000591456/Downstream/40511;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/157509, chr1-CpG: 89/Downstream/51638
Upstream sequence
TTATATTTTGGTCTTACAAATGATCACTTTTAAATGGACTTTTCTGTAAGAATGTAAAACTCAAAAATTTGCCAAGTATGTATCTGATCCACACAAATCC
Downstream sequence
CTAGAAAGGTTTTCTGTGTAGTCTTCATTAACGCAAATCTTTGTGAATGTTTCACTCTTACTGTAGGATCTTGAATATGTTTTACAATAATGAAGCTACA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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