Basic Information
VIS ID
TVIS44009942
Fusion event
HTLV-1-ANKRD28 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
15793236/15751729 (Hg38)
End
15793236/15751729 (Hg38)
Orient
-
Location type
Intronic
Target gene
ANKRD28
miRNAs that regulate target gene
hsa-mir-132-3p ; hsa-mir-21-5p ; hsa-mir-221-3p ; hsa-mir-130b-5p ; hsa-mir-3180-5p ; hsa-mir-513b-5p ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-561-3p ; hsa-mir-548at-5p ; hsa-mir-5195-3p ; hsa-mir-145-5p ; hsa-mir-6885-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-4753-3p ; hsa-mir-6873-3p ; hsa-mir-942-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-3617-3p ; hsa-mir-3074-3p ; hsa-mir-3614-3p
Nearest miRNA
hsa-mir-12127/Upstream/54358; hsa-let-7g/Downstream/122042;
Nearest TSS
ENST00000440867/Upstream/30607; ENST00000470031/Downstream/4818;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/149655, chr3-CpG: 142/Downstream/107261
Upstream sequence
CAGTCAAGGTATCTCAGTAGCTTTTCCTTCTTTTGAAAACATAGAATTTGAATATGGATTCAGGGGTACGCCTATTTAATGTTTTCATATAAAACATATT
Downstream sequence
TACTAAGAGAAATTTCATACCTCACTACAAGATGCAACTGCTCTGTGTAAAGGTGTCAACCATTTGCTGTCTTTGGCATTAACTCTAGCTCCTGCAACAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate